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Wednesday, October 21, 2020 | History

2 edition of Microiontophoretic studies of respiratory related neurones in the rat medulla. found in the catalog.

Microiontophoretic studies of respiratory related neurones in the rat medulla.

Aethena Patricia Law

Microiontophoretic studies of respiratory related neurones in the rat medulla.

by Aethena Patricia Law

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Published by University ofBirmingham in Birmingham .
Written in English


Edition Notes

Thesis (M.Sc.) - University of Birmingham, Dept of Pharmacology.

ID Numbers
Open LibraryOL13802529M

  We tested the hypothesis that pacemaker neurons generate breathing rhythm in mammals. We monitored respiratory-related motor nerve rhythm in neonatal rodent slice preparations. Blockade of the persistent sodium current (INaP), which was postulated to underlie voltage-dependent bursting in respiratory pacemaker neurons, with riluzole (≤ μM) did not alter the frequency of respiratory.   Obstructive sleep apnoea is a common and serious breathing problem that is caused by effects of sleep on pharyngeal muscle tone in individuals with narrow upper airways. There has been increasing focus on delineating the brain mechanisms that modulate pharyngeal muscle activity in the awake and asleep states in order to understand the pathogenesis of obstructive apnoeas and to .

  - located in the brainstem along the length of the medulla with a small portion in the lower pons Brainstem, dorsal view: is a part of the dorsal vagal complex (DVC), together with area postrema and dorsal motor nucleus of the vagus - is divided into rostral and caudal regions - has probably a very similar location in human, mouse and rat brains. The respiratory center is located in the medulla oblongata and pons, in the brainstem which are in hind brain before medulla and pons. The respiratory center is made up of three major respiratory groups of neurons, two in the medulla and one in the the medulla they are the dorsal respiratory group, and the ventral respiratory group.

State-dependent reductions in serotonin delivery to upper airway dilator motoneuron activity may contribute to sleep apnea. The functional significance of serotonin receptor subtypes implicated in excitation of dilator motor neurons was evaluated in anesthetized, paralyzed, mechanically ventilated adult rats (n = ). The effects of antagonists selective for serotonin receptor subtypes 2A, 2C. The ventromedial medulla is implicated in a variety of functions including nociceptive and cardiovascular modulation and the control of thermoregulation. To determine whether single microinjections.


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Microiontophoretic studies of respiratory related neurones in the rat medulla by Aethena Patricia Law Download PDF EPUB FB2

Abstract. There is an increasing tendency to combine multidisciplinary methods in studying the central nervous systems. One recently developed technique is the combination of electrophysiological and pharmacological investigations by making intracellular recording during extracellular iontophoresis of drugs to study the effects of neurotransmitters on neuronal activity and : Qi Jian Sun, Paul M.

Pilowsky. The transverse medullary slice preparation of neonatal rats has been used to study respiratory rhythm generation (Smith et al. ; Rekling & Feldman, ; Richter & Spyer, ).In this preparation, hypoglossal nerve rootlets generate spontaneous rhythmic discharges (Al-Zubaidy et al.

; Peever et al. ), which are synchronous with the firing of neurones in the pre-Bötzinger Cited by: P.B. Bradley, A.P. Lucy, Cholinoceptive properties of respiratory neurones in the rat medulla, Neuropharmacology, /(83), 22, 7, (), (). Crossref G ran Wahlstr m, The interaction between electrically induced convulsions and tolerance in the abstinence period after chronic barbital treatments in the rat Cited by:   The effects of four anilidopiperidine analgesics, fentanyl, sufentanil, lofentanil and alfentanil on the activity of single neurones in the rat brain stem were examined using the technique of microiontophoresis.

Neurones whose discharge rate could be related to respiration and non-respiratory neurones were by: 6. Eight different types of respiratory cells were found between and mm lateral to midline, extending mm caudal to mm rostral to obex, and mm below the dorsal surface.

A study of the respiratory motor (diaphragm EMG) and neuronal responses to excitatory amino acid (EAA) stimulation of the NTS areas was by: Naoyuki Inagaki, Yoshinori Kamisaki, Hiroshi Kiyama, Yoshiyuki Horio, Masaya Tohyama, Hiroshi Wada, Immunocytochemical localizations of cytosolic and mitochondrial glutamic oxaloacetic transaminase isozymes in rat primary sensory neurons as a marker for the glutamate neuronal system, Brain Research, /(87),1, ( The experimental techniques for microiontophoretic studies of single neurones in urethane-anaesthetised rats have been described in detail elsewhere (Bradley and Dray, ).

The cells studied were located in the reticular formation and the majority were identified histologically (Boakes, Bramwell, Briggs, Candy and Tempesta, ). The effects of microiontophoretically applied morphine and its interactions with the effects of microiontophoretic applications of either acetylcholine, (–)‐noradrenaline or 5‐hydroxytryptamine have been studied on single neurones in the brain stem of rats anaesthetized with urethane.

Request PDF | Microiontophoretic Study of Individual Neurons During Intracellular Recording | There is an increasing tendency to combine multidisciplinary methods in studying the central nervous.

The effects of iontophoretically applied acetylcholine, the acetylcholine agonists nicotine and muscarine, and the antagonists atropine, dihydro-β-erythroidine (DHβE) and mecamylamine, together with the excitatory amino acids, glutamate and d,l-homocysteic acid (DLH) were examined on the activity of respiratory-related neurones in the rat medulla and were compared with effects on.

The respiratory index η 2 (a variable ranging from 0–1 used to quantify the degree of respiratory modulation of brainstem neurons) 18 was only ± for RTN CO 2-activated neurons.

Boakes RJ, Bramwell GJ, Briggs I, Candy JM, Tempesta E. Localization with Pontamine Sky Blue of neurones in the brainstem responding to microiontophoretically applied compounds.

Neuropharmacology. Jun; 13 (6)– Bradley PB, Dray A. Morphine and neurotransmitter substances: Microiontophoretic study in the rat brain stem. Purchase The Rat Nervous System - 4th Edition. Print Book & E-Book.

ISBNFlora Licata, Guido Li Volsi, Michela Di Mauro, Giovanna Fretto, Lucia Ciranna, Francesca Santangelo, Serotonin Modifies the Neuronal Inhibitory Responses to γ-Aminobutyric Acid in the Red Nucleus: A Microiontophoretic Study in the Rat, Experimental Neurology, /exnr,1. A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text.

As a first approach, neurons (n = ) in the caudal region of the medulla, in an extension overlapping Loeshcke's area, were classified by their bioelectric activities as: (a) R (n = 51), spontaneously active and related to the respiratory cycle or (b) NR (n = 66), spontaneously active but not related to the respiratory cycle.

Electrophysiological properties of rostral ventrolateral medulla presympathetic neurons modulated by the respiratory network in rats. J Neurosci. ; – doi: /JNEUROSCI Crossref Medline Google Scholar; Abdala AP, McBryde FD, Marina N, Hendy EB, Engelman ZJ, Fudim M, Sobotka PA, Gourine AV, Paton JF.

The study was performed using iontophoretic applications of drugs on bulbar respiratory neurones. On these neurones GABA and glycine-sensitive sites were identified and differentiated on the basis of the actions of agonist (muscimol) or antagonists (bicuculline, picrotoxin and strychnine).

Novel data supporting the two respiratory rhythm oscillator hypothesis. Focus on "respiratory-related rhythmic activity in the rostral medulla of newborn rats", J Neurophysiol, ; 96(1): Janczewski Wiktor A, Feldman Jack L Novel data supporting the two respiratory.

of respiratory-s mpathetic synchronization. 3+ Divalent calcium antagonists, Co and M~~+, blockers of synaptic transmission, uncoupled respiratory oscillator and sympathetic activity. PAA neurons act as an interphase between different subsets of respiratory neurons and bulbospinal sympathoexcitatory neurons in rostra1 ventrolateral medulla (RVLM).

Medulla Oblongata Subject Areas on Research.Book Chapters. Kumar Carrive P; Kumar NN,'Adaptation of Respiratory-Related Brain Regions to Long-Term Hypercapnia: Focus on Lonergan T; McMullan S; Goodchild AK,'Distribution and neurochemical characterization of neurons in the rat ventrolateral medulla activated by glucoprivation', Brain Structure.

The medulla oblongata sits between the pons and the spinal cord. Its ventral (anterior) surface faces the basilar part of occipital bone and the dens of axis (C2), separated from them by the meninges and ligaments of the atlanto-occipital and atlantoaxial joints The dorsal (posterior) surface of the medulla faces the fourth ventricle of the brain.